Institute of Animal Nutrition, University of Veterinary Medicine Vienna, A-1210 Vienna, Austria.
Toxins (Basel). 2011 Jun;3(6):566-90. doi: 10.3390/toxins3060566. Epub 2011 Jun 14.
Aflatoxin B(1) is a common contaminant of poultry feeds in tropical and subtropical climates. Research during the last five decades has well established the negative effects of the mycotoxin on health of poultry. However, the last ten years of relevant data have accentuated the potential of low levels of aflatoxin B(1) to deteriorate broiler performance. In this regard, any attempt to establish a dose-effect relationship between aflatoxin B(1) level and broiler performance is also complicated due to differences in types of broilers and length of exposure to the mycotoxin in different studies. Contrary to the prevalent notion regarding literature saturation with respect to aflatoxicosis of chicken, many areas of aflatoxicosis still need to be explored. Literature regarding effects of the mycotoxin on the gastrointestinal tract in this regard is particular scanty and non-conclusive. In addition to these issues, the metabolism of aflatoxin B(1) and recently proposed hypotheses regarding biphasic effects of the mycotoxin in broilers are briefly discussed.
黄曲霉毒素 B(1) 是热带和亚热带气候下家禽饲料的常见污染物。在过去的五十年中，研究已经充分证实了这种霉菌毒素对家禽健康的负面影响。然而，过去十年的相关数据强调了低水平的黄曲霉毒素 B(1) 可能会降低肉鸡的生产性能。在这方面，由于不同研究中肉鸡的类型和接触霉菌毒素的时间长短不同，试图建立黄曲霉毒素 B(1)水平与肉鸡生产性能之间的剂量-效应关系也变得复杂。与关于鸡黄曲霉中毒文献饱和的普遍观点相反，黄曲霉中毒仍有许多领域需要探索。关于霉菌毒素对胃肠道影响的文献尤其缺乏且没有定论。除了这些问题，本文还简要讨论了黄曲霉毒素 B(1)的代谢以及最近提出的关于霉菌毒素在肉鸡中双相作用的假说。
