特定的人类白细胞抗原（HLA）抗原是否易患缺血性心脏病或特发性扩张型心肌病？
Do specific HLA antigens predispose to ischaemic heart disease or idiopathic dilated cardiomyopathy?
作者信息
Grant S C, Sheldon S, Dyer P A, Levy R D, Brooks N H
机构信息
Department of Cardiology, Wythenshawe Hospital, Manchester.
出版信息
Br Heart J. 1994 Jan;71(1):76-8. doi: 10.1136/hrt.71.1.76.
BACKGROUND
The aetiology of idiopathic dilated cardiomyopathy is believed to have an immunological component. Association with human leucocyte antigens (HLAs) has been previously reported, particularly with HLA-DR4.
AIM
To determine the association of HLA type with diagnosis in a group of patients assessed for heart transplantation.
METHODS
A comparison was made of frequencies of HLA types in patients with a diagnosis of idiopathic dilated cardiomyopathy or (n = 98) ischaemic heart disease (n = 170) and in controls from the North Western region (n = 857).
RESULTS
Neither the patients with idiopathic dilated cardiomyopathy nor those with ischaemic heart disease showed a significant increase or decrease in any HLA frequency compared with the controls.
CONCLUSION
These results suggest that there is no HLA association with idiopathic dilated cardiomyopathy or ischaemic heart disease. This conflicts with the results of some previous studies.
背景
特发性扩张型心肌病的病因被认为有免疫成分。此前已有与人类白细胞抗原（HLA）相关的报道，尤其是与HLA - DR4相关。
目的
确定在一组接受心脏移植评估的患者中HLA类型与诊断之间的关联。
方法
对诊断为特发性扩张型心肌病的患者（n = 98）、缺血性心脏病患者（n = 170）以及西北地区的对照组（n = 857）的HLA类型频率进行比较。
结果
与对照组相比，特发性扩张型心肌病患者和缺血性心脏病患者的任何HLA频率均未出现显著增加或减少。
结论
这些结果表明，HLA与特发性扩张型心肌病或缺血性心脏病无关联。这与之前一些研究的结果相矛盾。
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