Moser E, Moser M B, Andersen P
Department of Neurophysiology, University of Oslo, Norway.
Neuroreport. 1993 Dec 13;5(3):317-20. doi: 10.1097/00001756-199312000-00035.
To investigate whether hippocampal synaptic transmission is enhanced during learning, we recorded synaptic field potentials in the dentate gyrus in response to stimulation of the perforant path in rats exploring a novel environment. Because these signals rapidly grow during brain temperature elevation, caused by any motor activity, the potentials were compared with signals sampled at similar brain temperatures after passive warming. Both the field excitatory postsynaptic potential (f-EPSP) and the population spike increased significantly early in the exploration, relative to temperature-matched control potentials. The effect decayed within 15-30 minutes. This is the first demonstration of a temperature-independent synaptic potentiation in the hippocampus during learning about the environment. The time course is similar to that of short-term potentiation.
为了研究在学习过程中海马体突触传递是否增强，我们在大鼠探索新环境时，记录了齿状回中响应穿通通路刺激的突触场电位。由于这些信号在任何运动活动引起的脑温升高期间会迅速增强，因此将这些电位与被动升温后在相似脑温下采样的信号进行了比较。相对于温度匹配的对照电位，在探索早期，场兴奋性突触后电位（f-EPSP）和群体峰电位均显著增加。这种效应在15 - 30分钟内衰减。这是首次证明在学习环境过程中海马体中存在与温度无关的突触增强作用。其时程与短期增强相似。
