Sutherland R J, Dringenberg H C, Hoesing J M
Department of Psychology, University of New Mexico, Albuquerque 87131-1161.
Hippocampus. 1993 Apr;3(2):141-7. doi: 10.1002/hipo.450030206.
In two experiments the authors failed to detect an effect of inducing bilateral, long-lasting synaptic potentiation at perforant path dentate synapses on spatial learning by rats in the Morris place navigation task. Daily sessions of high-frequency stimulation of perforant path axons produced large increases to an asymptotic level in population spike and field excitatory postsynaptic potential recorded in ipsilateral dentate gyrus. Place learning proceeded normally 24 hours after the last of 14 high-frequency stimulation sessions in rats that had previously mastered the procedural aspects of place navigation (Experiment 1) and in rats that were naive (Experiment 2).
在两项实验中，作者未能检测到在莫里斯位置导航任务中，对大鼠穿通通路-齿状突触诱导双侧、持久的突触增强对空间学习的影响。每天对穿通通路轴突进行高频刺激，可使同侧齿状回记录的群体峰电位和场兴奋性突触后电位大幅增加至渐近水平。在先前已掌握位置导航程序方面的大鼠（实验1）和未经训练的大鼠（实验2）中，在14次高频刺激 sessions 中的最后一次之后24小时，位置学习正常进行。 （注：这里sessions根据语境推测可能是“训练时段”之类的意思，但按照要求未作修改）
