乙二胺四乙酸二钠（EDTA）对动脉粥样硬化患者的血脂没有影响。一项随机、安慰剂对照研究。
Disodium-ethylene diamine tetraacetic acid (EDTA) has no effect on blood lipids in atherosclerotic patients. A randomized, placebo-controlled study.
作者信息
Guldager B, Faergeman O, Jørgensen S J, Nexø E, Jelnes R
机构信息
Department of Medicine, Hillerød Hospital.
出版信息
Dan Med Bull. 1993 Nov;40(5):625-7.
OBJECTIVE
To study whether intravenous disodium-ethylene diamine tetraacetic acid (EDTA) affects blood lipids in patients with intermittent claudication.
DESIGN
Double-blind, randomized, placebo-controlled trial.
PARTICIPANTS
Twenty-nine patients with intermittent claudication (systolic ankle-brachial blood pressure index < 0.8; pain free walking distance 50-200 m).
INTERVENTION
3 g EDTA or placebo (isotonic saline) per infusion over a period of 5-9 weeks to a total of 57 g EDTA. Patients received vitamins, minerals and trace-elements daily.
RESULTS
14 patients received EDTA and 15 placebo. There was no statistically significant difference in the plasma concentration of cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol or triglyceride between the 2 groups.
CONCLUSION
Treatment with EDTA does not alter blood lipids in patients with intermittent claudication.
目的
研究静脉注射乙二胺四乙酸二钠（EDTA）是否会影响间歇性跛行患者的血脂水平。
设计
双盲、随机、安慰剂对照试验。
参与者
29例间歇性跛行患者（收缩期踝肱血压指数<0.8；无痛行走距离50-200米）。
干预措施
每次输注3克EDTA或安慰剂（等渗盐水），持续5-9周，EDTA总量达57克。患者每天补充维生素、矿物质和微量元素。
结果
14例患者接受EDTA治疗，15例接受安慰剂治疗。两组之间血浆胆固醇、低密度脂蛋白（LDL）胆固醇、高密度脂蛋白（HDL）胆固醇或甘油三酯浓度无统计学显著差异。
结论
EDTA治疗不会改变间歇性跛行患者的血脂水平。
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