Bouvard M P, Paris P, Dugas M
Service de Psychopathologie de l'Enfant et de l'Adolescent, Hôpital R. Debré, Paris.
Encephale. 1993 Aug;19 Spec No 3:473-9.
Outcome of depressive disorder in adolescents is now better known. Despite methodological differences between studies there is an agreement to emphasize frequency of relapse and recurrence in the follow-up (50 to 60%). Others modalities have also been described, anxiety disorders seemed to be the more frequent. For some authors, affective disorder in adolescents could presage manic depressive illness. Psychosocial functioning after the follow-up seems to be impaired as well as in professional, relational, or social fields. These data suggest a clear distinction between affective states in adolescents and symptoms related to psychological transformations of adolescence. We have conducted a follow-up study with adolescents hospitalized in the child and adolescent psychiatric department of R. Debré hospital, for major depressive episode (MDE) or dysthymic disorder (DD). On the 122 patients meeting initially inclusion criteria, 75 have been evaluated after one year follow-up at least. Duration of the follow-up was on average 4 years. 44 met initially DSM III and DSM III-R criteria for MDE and 31 for DD. Rating has been done during a phone interview with a standardized questionnaire. We did use criteria defined by Prien et al. (1984) for relapse, recurrence and remission. Our results showed a good short-term outcome in both groups (72.7% remission in MDE and 80.6% in DD). Relapse rate was superior in the first group. At the end of the follow-up, cumulative probability of recurrence was 52.9% in MDE group and 35.7% in DD group. Chronic evolution was more frequent in TD group.(ABSTRACT TRUNCATED AT 250 WORDS)
青少年抑郁症的预后如今已为人所知。尽管各研究在方法上存在差异,但在随访中都一致强调复发和再发的频率(50%至60%)。还描述了其他一些情况,焦虑症似乎更为常见。对一些作者而言,青少年情感障碍可能预示着双相情感障碍。随访后的心理社会功能在职业、人际关系或社交领域似乎也受到了损害。这些数据表明青少年的情感状态与青春期心理转变相关症状之间存在明显区别。我们对在R.德布雷医院儿童和青少年精神科住院的青少年进行了一项随访研究,这些青少年患有重度抑郁发作(MDE)或恶劣心境障碍(DD)。在最初符合纳入标准的122名患者中,至少有75名在一年随访后接受了评估。随访时间平均为4年。44名最初符合MDE的DSM III和DSM III - R标准,31名符合DD标准。通过电话访谈使用标准化问卷进行评分。我们采用了Prien等人(1984年)定义的复发、再发和缓解标准。我们的结果显示两组的短期预后都较好(MDE组缓解率为72.7%,DD组为80.6%)。第一组的复发率更高。随访结束时,MDE组的累积再发概率为52.9%,DD组为35.7%。TD组慢性病程更为常见。(摘要截取自250字)