McMurray J, Chopra M, Abdullah I, Smith W E, Dargie H J
Department of Cardiology, Western Infirmary, Glasgow, Scotland.
Eur Heart J. 1993 Nov;14(11):1493-8. doi: 10.1093/eurheartj/14.11.1493.
Chronic heart failure (CHF) due to coronary artery disease (CAD) has been shown to be associated with increased plasma thiobarbituric reactive substances (TBARS) and reduced plasma thiol (PSH) concentrations, suggesting oxidative stress (OS). The aims of the present studies were (a) to determine whether OS is due to CAD or CHF per se and (b) to determine if a wider range of more specific markers of OS are abnormal in CHF. In the first study, two groups of patients (n = 15 each) were compared. Group 1 (11 male, mean age 56 years) had CHF due to CAD and group 2 (12 male, mean age 53 years) had non-CAD CHF. Median plasma TBARS in controls was 7.6 nmol.ml-1, 10.0 nmol.ml-1 in group 1 and 9.3 nmol.ml-1 in group 2 (P < 0.01 both groups vs control). Median PSH was 505 384 and 364 nmol.ml-1 (P < 0.05 and P < 0.01 vs control) respectively. Fifty-three patients with CHF were recruited in the second study. Malondialdehyde and PSH were 10.3 and 409 nmol.ml-1 respectively, compared to control values of 7.9 and 560 nmol.ml-1 (both P < 0.001). The median values for the following additional measures of OS in controls and patients were: erythrocyte superoxide dismutase 131 vs 114 U.l-1 (P = 0.005); caeruloplasmin oxidase 97 vs 197 U.l-1 (P < 0.01); erythrocyte glutathione 1.56 nmol.ml-1 vs 1.77 nmol.ml-1 (P < 0.02); plasma conjugated dienes 0.28 vs 0.33 optical density units (P = ns).(ABSTRACT TRUNCATED AT 250 WORDS)
冠状动脉疾病（CAD）所致的慢性心力衰竭（CHF）已被证明与血浆硫代巴比妥酸反应性物质（TBARS）升高及血浆硫醇（PSH）浓度降低有关，提示存在氧化应激（OS）。本研究的目的是：（a）确定氧化应激是由CAD还是CHF本身所致；（b）确定在CHF中是否有更广泛的一系列更特异的氧化应激标志物异常。在第一项研究中，比较了两组患者（每组n = 15）。第1组（11名男性，平均年龄56岁）因CAD导致CHF，第2组（12名男性，平均年龄53岁）为非CAD所致的CHF。对照组血浆TBARS中位数为7.6 nmol/ml，第1组为10.0 nmol/ml，第2组为9.3 nmol/ml（两组与对照组相比，P均< 0.01）。PSH中位数分别为505、384和364 nmol/ml（与对照组相比，P分别< 0.05和< 0.01）。第二项研究纳入了53例CHF患者。丙二醛和PSH分别为10.3和409 nmol/ml，而对照组值分别为7.9和560 nmol/ml（均P < 0.001）。对照组和患者的以下其他氧化应激指标的中位数分别为：红细胞超氧化物歧化酶131对114 U/l（P = 0.005）；铜蓝蛋白氧化酶97对197 U/l（P < 0.01）；红细胞谷胱甘肽1.56 nmol/ml对1.77 nmol/ml（P < 0.02）；血浆共轭二烯0.28对0.33光密度单位（P = 无显著性差异）。（摘要截短于250字）
