Bridges A B, Scott N A, Pringle T H, McNeill G P, Belch J J
Department of Medicine, Ninewells Hospital and Medical School, Dundee, Scotland.
Clin Cardiol. 1992 Mar;15(3):169-74. doi: 10.1002/clc.4960150307.
Clinical studies have demonstrated that patients with coronary artery disease (CAD) have markers suggestive of increased free radical (FR) activity when compared with normal subjects; however, the relationship between the extent of CAD and level of FR markers is not known. The following indices of FR activity, plasma malondialdehyde (MDA), plasma thiols (PSH), red blood cell (RBC) glutathione (GSH), and RBC superoxide dismutase (SOD) were measured in 58 patients admitted for coronary angiography and in 50 matched controls. Regression analysis demonstrated no significant correlation between MDA, PSH, GSH, or SOD, and the angiographic grade which indicated the severity of the CAD. Patients with angiographically proven CAD (median 7.9 nmol/ml IQR 6.9-9.2) and patients with a history suggestive of angina pectoris but normal coronary angiograms (median 8.4 nmol/ml IQR 7.4-9.9) had significantly raised MDA levels compared with the controls (median 6.85 nmol/ml IQR 6.1-7.4), p less than 0.001 and p less than 0.005, respectively. The patients with angiographically proven CAD had significantly lower GSH levels (median 1461 microM IQR 1348-1709, p less than 0.002) compared with the controls (median 1754 microM IQR 1492-1930). Significantly raised SOD levels also were detected in patients with angiographically proven CAD (median 121.8 U/ml RBC, IQR 113.8-143.9) and in patients with a history of suggestive of angina pectoris but normal coronary angiograms (median 146 U/ml RBC, IQR 96.8-156.7) when compared with controls (median 96.3 U/ml RBC, IQR 82.4-115.6), p less than 0.001 and p less than 0.02, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
临床研究表明，与正常受试者相比，冠心病（CAD）患者具有提示自由基（FR）活性增加的标志物；然而，CAD的严重程度与FR标志物水平之间的关系尚不清楚。对58例因冠状动脉造影入院的患者和50例匹配的对照组测定了以下FR活性指标：血浆丙二醛（MDA）、血浆硫醇（PSH）、红细胞（RBC）谷胱甘肽（GSH）和红细胞超氧化物歧化酶（SOD）。回归分析表明，MDA、PSH、GSH或SOD与表明CAD严重程度的血管造影分级之间无显著相关性。与对照组（中位数6.85 nmol/ml，四分位间距6.1 - 7.4）相比，经血管造影证实患有CAD的患者（中位数7.9 nmol/ml，四分位间距6.9 - 9.2）和有典型心绞痛病史但冠状动脉造影正常的患者（中位数8.4 nmol/ml，四分位间距7.4 - 9.9）的MDA水平显著升高，p值分别小于0.001和小于0.005。与对照组（中位数1754 μM，四分位间距1492 - 1930）相比，经血管造影证实患有CAD的患者GSH水平显著降低（中位数1461 μM，四分位间距1348 - 1709，p值小于0.002）。与对照组（中位数96.3 U/ml RBC，四分位间距82.4 - 115.6）相比，经血管造影证实患有CAD的患者（中位数121.8 U/ml RBC，四分位间距113.8 - 143.9）和有典型心绞痛病史但冠状动脉造影正常的患者（中位数146 U/ml RBC，四分位间距96.8 - 156.7）的SOD水平也显著升高，p值分别小于0.001和小于0.02。（摘要截短于250字）
