Smolowitz R M, Reinisch C L
Laboratory for Marine Animal Health, School of Veterinary Medicine, University of Pennsylvania.
Dev Comp Immunol. 1993 Nov-Dec;17(6):475-81. doi: 10.1016/s0145-305x(05)80003-5.
The ontogeny of circulating hemocytes and tumor cells in mollusks has been approached using monoclonal antibodies to normal cells. A monoclonal antibody, previously shown to identify an adhesion related protein (p130), has been used to define the reactivity of cells in tissues from normal soft-shell clams (Mya arenaria) and soft-shell clams with leukemia. Using immunoperoxidase technology, we have determined that hemocytes, connective tissue cells, and a subset of leukemia cells that are adherent share a cross-reactive epitope with cilia.
利用针对正常细胞的单克隆抗体，研究了软体动物循环血细胞和肿瘤细胞的个体发生。一种先前已证明可识别粘附相关蛋白（p130）的单克隆抗体，被用于确定正常软壳蛤（砂海螂）和患白血病的软壳蛤组织中细胞的反应性。通过免疫过氧化物酶技术，我们已确定血细胞、结缔组织细胞以及一部分具有粘附性的白血病细胞与纤毛共享一个交叉反应表位。
