Szabo G, Urry D W
Science. 1979 Jan 5;203(4375):55-7. doi: 10.1126/science.83000.
Substitution of a methyl group for the N-terminal hydrogen of gramicidin greatly increased the rate of dissociation of conductive channels in lipid bilayer membranes. The finding of short lifetimes for conductive channels, comparable to those seen for the neuromuscular junction, lends support to the head-to-head dimer structure for the conductive channel.
用甲基取代短杆菌肽N端的氢，极大地提高了脂质双层膜中导电通道的解离速率。导电通道的短寿命与神经肌肉接头处的情况相当，这一发现支持了导电通道的头对头二聚体结构。
