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脑膜炎奈瑟菌获取血红素铁不涉及脑膜炎球菌转铁蛋白结合蛋白。

Acquisition of heme iron by Neisseria meningitidis does not involve meningococcal transferrin-binding proteins.

作者信息

Martel N, Lee B C

机构信息

Department of Microbiology and Infectious Diseases, University of Calgary, Alberta, Canada.

出版信息

Infect Immun. 1994 Feb;62(2):700-3. doi: 10.1128/iai.62.2.700-703.1994.

DOI:10.1128/iai.62.2.700-703.1994
PMID:8300227
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC186161/
Abstract

Similarities in size between hemin-binding protein 1 (HmBP1) and transferrin-binding protein 1 (TBP1) of Neisseria meningitidis suggest that these proteins are functionally homologous. However, a meningococcal mutant lacking the transferrin-binding proteins retained the capacity to acquire iron from heme and hemoglobin. In immunoblots, hyperimmune polyclonal antiserum against TBP1 did not react with HmBP1.

摘要

脑膜炎奈瑟菌的血红素结合蛋白1（HmBP1）和转铁蛋白结合蛋白1（TBP1）在大小上的相似性表明这些蛋白在功能上是同源的。然而，一个缺乏转铁蛋白结合蛋白的脑膜炎球菌突变体仍保留了从血红素和血红蛋白获取铁的能力。在免疫印迹中，抗TBP1的超免疫多克隆抗血清不与HmBP1发生反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2153/186161/ac44011928db/iai00002-0384-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2153/186161/2a388b2cef97/iai00002-0383-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2153/186161/16f6504f3d57/iai00002-0383-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2153/186161/ac44011928db/iai00002-0384-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2153/186161/2a388b2cef97/iai00002-0383-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2153/186161/16f6504f3d57/iai00002-0383-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2153/186161/ac44011928db/iai00002-0384-a.jpg

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本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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Cloning and characterization of the Vibrio cholerae genes encoding the utilization of iron from haemin and haemoglobin.霍乱弧菌编码利用血红素和血红蛋白中铁元素的基因的克隆与特性分析。
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致病性奈瑟菌与非吞噬细胞的相互作用。
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Cloning and characterization of Neisseria meningitidis genes encoding the transferrin-binding proteins Tbp1 and Tbp2.编码转铁蛋白结合蛋白Tbp1和Tbp2的脑膜炎奈瑟菌基因的克隆与鉴定
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Affinity chromatography of heme-binding proteins: an improved method for the synthesis of hemin-agarose.血红素结合蛋白的亲和层析：一种改进的血红素琼脂糖合成方法。
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Iron acquisition by Neisseria meningitidis in vitro.脑膜炎奈瑟菌在体外获取铁的过程。
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