未麻醉去大脑猫的背侧耳蜗核暂停增强单元中，在短纯音爆发前的安静间隔期放电抑制。

Discharge suppression in the silent interval preceding the tone burst in pause-build units of the dorsal cochlear nucleus of the unanesthetized decerebrate cat.

作者信息

Parham K, Kim D O

机构信息

Department of Surgery, University of Connecticut Health Center, Farmington 06030.

出版信息

J Acoust Soc Am. 1993 Dec;94(6):3227-31. doi: 10.1121/1.407228.

DOI:10.1121/1.407228

PMID:8300957

Abstract

A recent intracellular study of dorsal cochlear nucleus (DCN) neurons in vitro by Manis [P. B. Manis, J. Neurosci. 10, 2338-2351 (1990)] suggests that the expression of the pause-build discharge pattern is in large part dependent on hyperpolarization of their membrane potentials in a period just preceding a depolarizing stimulus ("hyperpolarization conditioning" hypothesis). Our examination of the activity of a sample of pause-build units (n = 72) revealed suppression of discharge activity during a time window of the silent interstimulus interval (SII) just preceding the tone burst relative to the spontaneous rate in 74% of all units. The discharge suppression of a subset of DCN pause-build units in the SII satisfies a requirement of the "hyperpolarization conditioning" hypothesis, and thus supports the hypothesis.

摘要

马尼斯[P. B. 马尼斯，《神经科学杂志》10, 2338 - 2351 (1990)]最近在体外对蜗背侧核（DCN）神经元进行的一项细胞内研究表明，暂停增强放电模式的表达在很大程度上取决于在去极化刺激之前的一段时间内其膜电位的超极化（“超极化调节”假说）。我们对一组暂停增强单元（n = 72）的活动进行的检查发现，在74%的单元中，相对于自发发放率，在紧跟音调爆发之前的寂静刺激间隔（SII）的一个时间窗口内，放电活动受到抑制。SII中DCN暂停增强单元子集的放电抑制符合“超极化调节”假说的一个要求，因此支持了该假说。