Kucharz E J, Sierakowski S J, Goodwin J S
Fourth Department of Internal Medicine, Silesian University School of Medicine, Tychy, Poland.
Immunopharmacol Immunotoxicol. 1993 Nov;15(5):515-23. doi: 10.3109/08923979309019728.
Cellular immunity is impaired in patients with systemic lupus erythematosus (SLE). A decreased production of interleukin-2 by T cells isolated from blood of patients with SLE was found. The decrease correlated with severity of the disease. It was shown that incubation in vitro of T cells with 5 mM of lithium chloride augmented interleukin-2 production. The increase in cultures of T cells from patients with SLE was higher that than in healthy individuals. It is believed that lithium increases the cytosol inositol triphosphate level and subsequently augmented impaired intracellular signal transduction in the T cells from patients with SLE.
系统性红斑狼疮（SLE）患者的细胞免疫功能受损。研究发现，从SLE患者血液中分离出的T细胞产生白细胞介素-2的能力下降。这种下降与疾病的严重程度相关。结果表明，用5 mM氯化锂对T细胞进行体外培养可增加白细胞介素-2的产生。SLE患者T细胞培养物中的增加幅度高于健康个体。据信，锂可提高细胞质肌醇三磷酸水平，进而增强SLE患者T细胞中受损的细胞内信号转导。
