系统性红斑狼疮中的T细胞功能：白细胞介素2的正常产生及反应性
T cell function in systemic lupus erythematosus: normal production of and responsiveness to interleukin 2.
作者信息
Draeger A M, Swaak A J, van den Brink H G, Aarden L A
出版信息
Clin Exp Immunol. 1986 Apr;64(1):80-7.
To investigate the role of interleukin 2 (IL-2) in systemic lupus erythematosus (SLE) mononuclear cells (MNC) of 68 SLE patients were tested for their ability to produce and also to respond to IL-2. Cells were collected monthly over an one year period. IL-2 production by MNC was measured under various conditions after optimal and suboptimal stimulation. Although we found a large variation in IL-2 production by individual MNC preparations no statistical significant differences were found between normal and SLE cells. To study IL-2 responsiveness, proliferation of MNC was studied under conditions where endogenous IL-2 production is limiting. Addition of IL-2 resulted in a four- to eight-fold enhancement of proliferative responses. However also in this respect no differences were found between SLE patients and healthy controls. Thus, in this group of SLE patients no abnormalities in IL-2 production or response could be demonstrated.
为了研究白细胞介素2（IL-2）在系统性红斑狼疮（SLE）中的作用，检测了68例SLE患者单核细胞（MNC）产生IL-2以及对IL-2反应的能力。在一年的时间里每月采集细胞。在最佳和次优刺激后的各种条件下测量MNC产生的IL-2。虽然我们发现各个MNC制剂产生的IL-2有很大差异，但正常细胞和SLE细胞之间未发现统计学上的显著差异。为了研究IL-2反应性，在内源性IL-2产生受限的条件下研究MNC的增殖。添加IL-2导致增殖反应增强4至8倍。然而，在这方面SLE患者和健康对照之间也未发现差异。因此，在这组SLE患者中未发现IL-2产生或反应的异常。
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