Sierakowski S, Kucharz E J
Department of Rheumatology, Medical Academy in Bialystok, Poland.
Med Interne. 1988 Jan-Mar;26(1):67-73.
Interleukin-2 (IL-2) production was studied in T lymphocytes from 23 patients with systemic lupus erythematosus (SLE) and 20 healthy volunteers. The IL-2 production by phytohemagglutinin (PHA)-stimulated cells from SLE patients was significantly depressed as compared to control values. The depressed IL-2 production by SLE T cells was largely reversed by the addition of phorbol myristate acetate (PMA), which directly activates protein kinase C. This can explain why some authors using PMA together with mitogens were not able to find a depressed IL-2 production in SLE patients. These results suggest that the defect responsible for decreased IL-2 production by SLE lymphocytes is proximal to protein kinase C activation and that probably a very early event in T cell activation is responsible for impaired IL-2 response to mitogen in patients with SLE.
对23例系统性红斑狼疮（SLE）患者和20名健康志愿者的T淋巴细胞中白细胞介素-2（IL-2）的产生情况进行了研究。与对照值相比，SLE患者经植物血凝素（PHA）刺激的细胞产生的IL-2明显减少。添加直接激活蛋白激酶C的佛波醇肉豆蔻酸酯乙酸酯（PMA）后，SLE T细胞产生的IL-2减少情况在很大程度上得到了逆转。这可以解释为什么一些将PMA与丝裂原一起使用的作者未能发现SLE患者的IL-2产生减少。这些结果表明，SLE淋巴细胞产生IL-2减少的缺陷发生在蛋白激酶C激活的近端，并且可能T细胞激活过程中一个非常早期的事件导致了SLE患者对丝裂原的IL-2反应受损。
