Sparks D L, Danner F W, Davis D G, Hackney C, Landers T, Coyne C M
Sanders-Brown Center on Aging, University of Kentucky, Lexington.
J Neuropathol Exp Neurol. 1994 Jan;53(1):37-42. doi: 10.1097/00005072-199401000-00005.
In the course of investigating a large number of non-demented subjects, a 68 year old female dying of coronary artery disease was found to have Pick bodies in her grossly normal brain. Although only mild subcortical gliosis and no neuron loss were observed. Pick bodies were found throughout the brain and occasional balloon cells were noted. Pick bodies and numerous neurons were also ALZ-50 and Tau-1 immunoreactive. Retrospective studies indicated a lack of overt intellectual decline or depression in this individual. Frontal, temporal and occipital poles, amygdala, hypothalamus and nucleus basalis of Meynert (nbM) were analyzed for ChAT, AChE and MAO-A and -B enzymatic activities and for the binding of 5HT and imipramine. Cholinergic decreases were found only in subcortical structures. Serotonin binding decreases were widespread, excluding the nbM. Altered MAO-B activity was regionally variable, and no differences in MAO-A activity or imipramine binding were observed. Few differences in neurochemical alterations were observed in the current non-demented subject with abundant Pick bodies compared to previous studies of demented Pick's patients. This case strongly suggests that chemical dysfunction and neuropathological features of Pick's disease occur in advance of overt clinical manifestations of the disorder.
在对大量非痴呆受试者进行调查的过程中，发现一名死于冠状动脉疾病的68岁女性，其大体正常的大脑中存在Pick小体。尽管仅观察到轻度皮质下胶质细胞增生且无神经元丢失，但Pick小体遍布全脑，并偶见气球样细胞。Pick小体和众多神经元对ALZ - 50和Tau - 1也呈免疫反应阳性。回顾性研究表明该个体无明显智力衰退或抑郁症状。对额叶、颞叶和枕叶极、杏仁核、下丘脑以及Meynert基底核（nbM）进行了胆碱乙酰转移酶（ChAT）、乙酰胆碱酯酶（AChE）以及单胺氧化酶A和B（MAO - A和MAO - B）的酶活性分析，以及5-羟色胺（5HT）和丙咪嗪结合分析。胆碱能降低仅在皮质下结构中发现。5HT结合降低广泛存在，但nbM除外。MAO - B活性改变存在区域差异，未观察到MAO - A活性或丙咪嗪结合的差异。与先前对痴呆性Pick病患者的研究相比，在当前具有大量Pick小体的非痴呆受试者中观察到的神经化学改变差异不大。该病例强烈提示，Pick病的化学功能障碍和神经病理学特征在该疾病明显的临床表现之前就已出现。
