Sparks D L, Markesbery W R
Alzheimer's Disease Research Center/Sanders-Brown Center on Aging, Department of Pathology, University of Kentucky Medical Center, Lexington 40536-0230.
Arch Neurol. 1991 Aug;48(8):796-9. doi: 10.1001/archneur.1991.00530200032014.
Choline acetyltransferase and acetylcholinesterase activities as well as serotonin and imipramine binding were determined in the hypothalamus, nucleus basalis of Meynert, and frontal and temporal poles of subjects with Pick's disease. Choline acetyltransferase activity was decreased in the hypothalamus and nucleus basalis of Meynert, and acetylcholinesterase activity was decreased in the nucleus basalis of Meynert only. Serotonin binding was decreased in all sites but the nucleus basalis of Meynert, and imipramine binding was altered only in the frontal pole. Comparison with previous reports of Alzheimer's disease indicates that with respect to these synaptic markers, Alzheimer's disease and Pick's disease are not similar.
在患有匹克氏病的受试者的下丘脑、迈内特基底核以及额叶和颞叶中，测定了胆碱乙酰转移酶和乙酰胆碱酯酶的活性以及血清素和丙咪嗪的结合情况。胆碱乙酰转移酶活性在下丘脑和迈内特基底核中降低，而乙酰胆碱酯酶活性仅在迈内特基底核中降低。血清素结合在除迈内特基底核之外的所有部位均降低，丙咪嗪结合仅在额叶中发生改变。与先前关于阿尔茨海默病的报告相比表明，就这些突触标记而言，阿尔茨海默病和匹克氏病并不相似。
