Ito A, Ando K, Hayakawa T, Iwata T, Kayukawa Y, Ohta T, Kasahara Y
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan.
Jpn J Psychiatry Neurol. 1993 Sep;47(3):563-7. doi: 10.1111/j.1440-1819.1993.tb01800.x.
A response to treatment and long-term course of 14 adults with delayed sleep phase syndrome were investigated with the use of their hospital records and mailed questionnaires. Six patients treated with chronotherapy showed full recovery just after the treatment. In three of them the delay of sleep phase relapsed one year afterwards. Four of five patients treated with pharmacotherapy alone showed partial recovery. Six of nine patients followed for periods of longer than three years after treatment showed good prognoses, though all of them still had a mild phase delay and had to shorten their sleep time in order to work full-time. The three others had poor prognoses and one of them was under psychiatric treatment for affective instability. These findings suggest that a long-term follow-up is needed to judge the effect of the treatment.
通过医院记录和邮寄问卷对14名成人延迟睡眠相位综合征患者的治疗反应和长期病程进行了调查。6名接受时间疗法治疗的患者在治疗后立即完全康复。其中3人在一年后睡眠相位延迟复发。仅接受药物治疗的5名患者中有4名部分康复。9名患者在治疗后随访三年以上，其中6名预后良好，尽管他们所有人仍有轻度的相位延迟，并且为了全职工作不得不缩短睡眠时间。另外3名患者预后不佳，其中1人因情感不稳定正在接受精神治疗。这些发现表明，需要长期随访以判断治疗效果。
