Okuda B, Kawabata K, Tachibana H, Sugita M, Fukuchi M
Fifth Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
Jpn J Psychiatry Neurol. 1993 Sep;47(3):599-602. doi: 10.1111/j.1440-1819.1993.tb01805.x.
A case of motor neuron disease with dementia is presented. A brain CT showed atrophic changes mainly in the left frontal cortex, and 123I-IMP SPECT disclosed a decrease in 123I-IMP uptake in the frontal regions. To distinguish a subregion related to dementia from that related to motor system disorders, a three-dimensional surface display with 123I-IMP was reconstructed. The imaging method clearly demonstrated cortical hypoperfusion in the inferomedial frontal cortex and the motor-sensory cortex. These findings suggest that dementia may be due to the former lesion and motor system disorders due to the latter lesion, respectively.
本文报告一例伴有痴呆的运动神经元病病例。脑部CT显示主要为左侧额叶皮质萎缩性改变，123I-IMP单光子发射计算机断层显像（SPECT）显示额叶区域123I-IMP摄取减少。为了区分与痴呆相关的脑区和与运动系统障碍相关的脑区，利用123I-IMP重建了三维表面显像。该成像方法清晰显示了额下内侧皮质和运动感觉皮质的皮质灌注不足。这些发现提示，痴呆可能分别归因于前者的病变，而运动系统障碍则归因于后者的病变。
