用123I-IMP三维表面显示法证实皮质基底节变性中的局灶性皮质灌注不足：失用症的一个可能原因。

Focal cortical hypoperfusion in corticobasal degeneration demonstrated by three-dimensional surface display with 123I-IMP: a possible cause of apraxia.

作者信息

Okuda B, Tachibana H, Takeda M, Kawabata K, Sugita M, Fukuchi M

机构信息

Fifth Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.

出版信息

Neuroradiology. 1995 Nov;37(8):642-4. doi: 10.1007/BF00593379.

DOI:10.1007/BF00593379

PMID:8748895

Abstract

To clarify cortical lesions responsible for apraxia in cortico-basal degeneration (CBD), we reconstructed three-dimensional surface images from single-photon emission computed tomography (SPECT) data with N-isopropyl-p[I-123]-iodoamphetamine in two patients with CBD. Both had limb-kinetic apraxia (LKA) and one also had constructional apraxia (CA). Both showed asymmetrical cortical hypoperfusion in the perirolandic area. The patient with CA had unilateral hypoperfusion in the posterior parietal area. Thus, cortical hypoperfusion in the perirolandic area corresponded to LKA, and that in the posterior parietal area to CA.

摘要

为明确皮质基底节变性（CBD）中导致失用症的皮质病变，我们利用N-异丙基-p[I-123]-碘安非他明单光子发射计算机断层扫描（SPECT）数据，为两名CBD患者重建了三维表面图像。两名患者均有肢体运动性失用症（LKA），其中一名还患有结构性失用症（CA）。两人均在中央前回周围区域出现不对称皮质灌注不足。患有CA的患者在后顶叶区域出现单侧灌注不足。因此，中央前回周围区域的皮质灌注不足与LKA相关，而后顶叶区域的皮质灌注不足与CA相关。