Ribet M, Jaillard-Thery S, Nuttens M C
Service de chirurgie thoracique, Hôpital Calmette, Lille, France.
J Thorac Cardiovasc Surg. 1994 Feb;107(2):611-4.
Sixty-five patients, aged 15 to 65 years, including 48 men (73.8%), were operated on for pulmonary (60) or endobronchial (5) hamartoma: there were 36 enucleations, 17 lobectomies (1 sleeve resection), 7 wedge resections, 4 segmentectomies, and 1 pneumonectomy. The average tumor diameter was between 2 and 4 cm; 15 were calcified. All were benign. Two were parts of an incomplete Carney's triad. Eight were associated with carcinomas, and three of these were bronchial carcinomas. Concerning these latter three tumors, a study of the incidence tables for northern France and of the standardized mortality ratio showed that the risk of bronchial cancer developing in patients with hamartoma, after a sufficient follow-up (61 patients), was multiplied by 6.66, and the chi 2 test showed a significant difference of incidence compared with that in the general population (p < 0.001). It is concluded that patients with hamartoma should be submitted to a complete evaluation and to a regular follow-up.
65例年龄在15至65岁之间的患者接受了肺（60例）或支气管内（5例）错构瘤手术，其中包括48名男性（73.8%）：36例行摘除术，17例行肺叶切除术（1例袖状切除术），7例行楔形切除术，4例行肺段切除术，1例行全肺切除术。肿瘤平均直径在2至4厘米之间；15例有钙化。所有肿瘤均为良性。2例是不完全性卡尼三联征的一部分。8例与癌相关，其中3例为支气管癌。关于后3例肿瘤，对法国北部发病率表和标准化死亡比的研究表明，错构瘤患者在充分随访（61例患者）后发生支气管癌的风险增加了6.66倍，卡方检验显示与普通人群相比发病率有显著差异（p<0.001）。结论是，错构瘤患者应接受全面评估和定期随访。
