Holden R, Hesler J, Forbes J, Brown N A
Clinical Cataract Research Unit, Oxford, United Kingdom.
Optom Vis Sci. 1993 Nov;70(11):982-5. doi: 10.1097/00006324-199311000-00017.
Objective quantification of cataract and subjective assessment of visual performance are essential features of anticataract or cataractogenic drug trials. The constrains of a longitudinal trial require a compromise in contrast sensitivity measurement between sensitivity and speed. Such a system has been developed for use in longitudinal anticataract trials. An objective cataract assessment system has also been developed for these trials. Visual performance parameters and objectively measured grades of cataract using these systems were correlated in a group of patients with early lens opacities. Overall the correlation was poor in all three morphological types of cataract. Possible reasons for this and implications for future anticataract trials are discussed.
白内障的客观量化和视觉性能的主观评估是抗白内障或致白内障药物试验的基本特征。纵向试验的限制要求在对比敏感度测量的灵敏度和速度之间进行折衷。已经开发出一种用于纵向抗白内障试验的系统。还为这些试验开发了一种客观的白内障评估系统。在一组早期晶状体混浊患者中，使用这些系统的视觉性能参数与客观测量的白内障分级相关。总体而言，在所有三种形态类型的白内障中，相关性都很差。讨论了造成这种情况的可能原因以及对未来抗白内障试验的影响。
