Self T H, Heilker G M, Alloway R R, Kelso T M, Abou-Shala N
Department of Clinical Pharmacy, University of Tennessee, Memphis 38163.
Pharmacotherapy. 1993 Nov-Dec;13(6):590-4.
The therapeutic status of theophylline has changed dramatically over the last decade. As part of this change, a different view of the most appropriate therapeutic range for serum theophylline concentration (STC) has emerged. The National Institutes of Health Expert Panel Report, "Guidelines for the Diagnosis and Management of Asthma," suggests a conservative approach of aiming for STC of 5-15 micrograms/ml. This truly landmark document along with several studies in the literature, recently prompted us to change our hospital's laboratory report form for the medical record to read that the therapeutic range for STC is 5-15 micrograms/ml. We encourage hospital laboratories or other clinical laboratories who have not already made this change to do so.
在过去十年中，茶碱的治疗地位发生了巨大变化。作为这一变化的一部分，对于血清茶碱浓度（STC）最合适的治疗范围出现了不同的观点。美国国立卫生研究院专家小组报告《哮喘诊断与管理指南》建议采取保守方法，将STC目标设定为5 - 15微克/毫升。这份具有里程碑意义的文件以及文献中的几项研究，最近促使我们将医院病历的实验室报告形式改为STC的治疗范围为5 - 15微克/毫升。我们鼓励尚未做出这一更改的医院实验室或其他临床实验室进行更改。
