Permeability changes in the blood-brain barrier of neonate and adult rats after thiobencarb exposure.

Thiobencarb, an organocarbamate herbicide, induces toxic neuropathies in neonates and adults. Permeability changes in the blood brain barrier under thiobencarb stress in neonate and adult rats were assessed using the dye, trypan blue. Acute and subacute doses of thiobencarb increased the dye concentrations in the brains of both neonates and adults in a time dependent manner. Concentrations of the dye were found to be greater in neonate rat brains when compared to adult brains.