丁草胺胁迫下新生大鼠和成年大鼠大脑中乙酰胆碱酯酶和ATP酶活性变化的比较研究

Comparative study on the changes in AChE and ATPase activities in neonate and adult rat brains under thiobencarb stress.

作者信息

Pentyala S N, Chetty C S

机构信息

Department of Zoology, S.V. University, Tirupati A.P., India.

出版信息

J Appl Toxicol. 1993 Jan-Feb;13(1):39-42. doi: 10.1002/jat.2550130109.

DOI:10.1002/jat.2550130109

PMID:8440873

Abstract

Thiobencarb (S-(4-chlorobenzyl)-N,N-diethyl thiol carbamate), a dithiocarbamate herbicide, was found to cause neuronal dysfunction in adult and neonate albino rats. In general, organocarbamates exert their action by inhibiting acetylcholinesterase (AChE) activity. Thiobencarb inhibited both acetylcholinesterase and adenosine triphosphatase (ATPase) activities in rat brain. Withdrawal of thiobencarb treatment resulted in the recovery of AChE activity to a normal level, whereas there was no recovery of Na(+)-K(+)-ATPase activity in either neonate or adult rat brains. The results suggest that neuronal dysfunction caused by thiobencarb is mainly due to the inhibition of ATPase activity rather than to the inhibition of AChE activity.

摘要

杀草丹（S-(4-氯苄基)-N,N-二乙基硫代氨基甲酸酯），一种二硫代氨基甲酸盐类除草剂，被发现会导致成年和新生白化大鼠出现神经功能障碍。一般来说，有机氨基甲酸盐通过抑制乙酰胆碱酯酶（AChE）活性发挥作用。杀草丹抑制大鼠脑中的乙酰胆碱酯酶和三磷酸腺苷酶（ATPase）活性。停止杀草丹治疗后，AChE活性恢复到正常水平，而新生或成年大鼠脑中的Na(+)-K(+)-ATPase活性均未恢复。结果表明，杀草丹引起的神经功能障碍主要是由于ATPase活性受到抑制，而非AChE活性受到抑制。