Kiper D C
Howard Hughes Medical Institute, New York University, NY 10003.
Vision Res. 1994 Feb;34(4):437-47. doi: 10.1016/0042-6989(94)90158-9.
Human strabismus amblyopes show deficits in spatial vision that are revealed in a variety of visual tasks. In particular, they show severe deficits in their ability to encode the relative spatial phase of the sinusoidal components in a compound grating. To investigate the neural basis of strabismic amblyopia we tested the ability of monkeys with experimentally induced strabismus to encode spatial phase relationships. First, we trained them to discriminate between compound gratings (made of a fundamental sinusoid and its third harmonic) that differed only in the relative phase of their components. These monkeys exhibited a pattern of severe deficits that resemble those described in the human population of strabismic amblyopes. We conclude that these animals represent a valid model of strabismic amblyopia. Second, we show that a model that had been used to account for the performance of normal human subjects and of humans with anisometropic amblyopia fails to predict the performance of monkeys with strabismic amblyopia.
人类斜视性弱视患者在各种视觉任务中表现出空间视觉缺陷。特别是，他们在编码复合光栅中正弦成分的相对空间相位的能力上存在严重缺陷。为了研究斜视性弱视的神经基础，我们测试了实验性诱导斜视的猴子编码空间相位关系的能力。首先，我们训练它们区分仅在成分相对相位上不同的复合光栅（由一个基波正弦波及其三次谐波组成）。这些猴子表现出的严重缺陷模式与人类斜视性弱视患者中描述的相似。我们得出结论，这些动物代表了斜视性弱视的有效模型。其次，我们表明，一个曾用于解释正常人类受试者和屈光参差性弱视患者表现的模型，无法预测斜视性弱视猴子的表现。
