Nikolaeva L I, Bogomolova N N, Filimonova R G, Borisova V V, Tikhonova N T, Mamaeva T A, Naumova M A
Vopr Virusol. 1993 Nov-Dec;38(6):256-8.
The qualitative and quantitative analysis of antibodies to measles virus (MV) structural proteins (SP) in sera from patients with chronic glomerulonephritis (CGN), chronic active hepatitis (CAH), and liver cirrhosis (LC) was done. The patients were shown to have neutralizing antibody titres (NAT) higher than those in healthy subjects. An analysis of antibodies to SP was carried out by the radioimmunoprecipitation assay. Antibodies were detected to hemagglutinin, nucleoprotein (NP), fusion protein and to matrix protein (M) both in sera from the patients with these chronic diseases, healthy subjects, and patients with active measles. (The two latter groups were selected for comparison). However, some patients with CAH and LC had no antibodies to M protein in spite of very high NAT. The quantitative analysis of MV antibodies to SP was done only for NP because this antibody had the least individual variations. The quantity of anti-NP antibodies was higher in most sera from patients with chronic diseases than in those from healthy subjects, and reached the level of that in patients with active measles. The presence of MV genome in the peripheral blood lymphocytes from patients CAH, CGN, and LC had been shown earlier. So it is assumed that MV persists in lymphoid tissue where the expression of all SP genes is realized.
对慢性肾小球肾炎（CGN）、慢性活动性肝炎（CAH）和肝硬化（LC）患者血清中麻疹病毒（MV）结构蛋白（SP）抗体进行了定性和定量分析。结果显示，这些患者的中和抗体滴度（NAT）高于健康受试者。采用放射免疫沉淀法对SP抗体进行分析。在这些慢性病患者、健康受试者以及麻疹急性期患者的血清中均检测到了针对血凝素、核蛋白（NP）、融合蛋白和基质蛋白（M）的抗体。（选择后两组作为对照）。然而，部分CAH和LC患者尽管NAT很高，但却没有针对M蛋白的抗体。仅对NP进行了MV针对SP抗体的定量分析，因为该抗体个体差异最小。大多数慢性病患者血清中抗NP抗体的量高于健康受试者，且达到了麻疹急性期患者的水平。先前已证实CAH、CGN和LC患者外周血淋巴细胞中存在MV基因组。因此推测MV在淋巴组织中持续存在，在该组织中所有SP基因均得以表达。
