Sahin Y, Saglam A
Department of Obstetrics and Gynecology, Erciyes University School of Medicine, Kayseri, Turkey.
Acta Obstet Gynecol Scand. 1994 Jan;73(1):70-3. doi: 10.3109/00016349409013399.
To investigate the effect of sodium carboxymethylcellulose (SCMC) and the combination of low molecular weight heparin (LMWH) with SCMC in the prevention of intraperitoneal adhesion.
Thirty-eight rats underwent bilateral surgical injury to the uterine horn and the parietal peritoneum. In 13 rats, a solution of SCMC was instilled at laparotomy. In 11 rats, LMWH was delivered on to serosal and peritoneal defects, and SCMC was instilled. As a control group 14 rats were included in the study.
Surgical Research Laboratory, Erciyes University.
Female Wistar-Albino rats, weighing 200 to 250 g each.
Adhesions between the uterine horn and the abdominal sidewall were scored for extent and severity two weeks after the initial surgery.
Although the mean adhesion score both in the SCMC group (2.8, s.d. 1.15) and in the SCMC with LMWH group (1.6, s.d 1.18) was found to be significantly lower than in the control group (3.4, s.d. 0.89) (p < 0.05 and p < 0.001, respectively), more favorable adhesion prophylaxis was achieved in the SCMC with LMWH group in comparison with the SCMC treatment group without any hemorrhagic complications (p < 0.001).
We conclude that SCMC with LMWH are highly effective in reducing postoperative adhesions in this animal model. SCMC with LMWH appears promising in adhesion prophylaxis.
探讨羧甲基纤维素钠（SCMC）以及低分子量肝素（LMWH）与SCMC联合使用在预防腹腔粘连方面的效果。
38只大鼠接受双侧子宫角和壁层腹膜手术损伤。13只大鼠在剖腹手术时注入SCMC溶液。11只大鼠在浆膜和腹膜缺损处给予LMWH并注入SCMC。14只大鼠作为对照组纳入研究。
埃尔西耶斯大学外科研究实验室。
雌性Wistar - 白化大鼠，每只体重200至250克。
初次手术后两周，对子宫角与腹壁之间的粘连程度和严重程度进行评分。
虽然SCMC组（均值2.8，标准差1.15）和LMWH与SCMC联合组（均值1.6，标准差1.18）的平均粘连评分均显著低于对照组（均值3.4，标准差0.89）（分别为p < 0.05和p < 0.001），但与无任何出血并发症的SCMC治疗组相比，LMWH与SCMC联合组在预防粘连方面效果更佳（p < 0.001）。
我们得出结论，LMWH与SCMC联合使用在该动物模型中对减少术后粘连非常有效。LMWH与SCMC联合使用在预防粘连方面似乎很有前景。
