Department of Hepatobiliary Surgery, the Norman Bethune First Hospital of Jilin University, Jilin, China.
Int J Med Sci. 2012;9(6):467-71. doi: 10.7150/ijms.4639. Epub 2012 Aug 9.
Intraperitoneal adhesion is a serious surgical postoperative complication. Using a rat model, we compared the effectiveness of intraperitoneally administered zinc-modified sodium carboxymethyl cellulose (Zn(2+)-SCMC) and hyaluronic acid (HA) in preventing postoperative intraperitoneal adhesions.
Peritoneal adhesions were induced in 120 Wistar rats by scraping the cecal mucosa. The rats were randomized into a no treatment group (n = 40) or into a treatment group in which 3 ml of HA (n = 40) or Zn(2+)-SCMC (n = 40) was administered intraperitoneally before the abdominal wall was closed. Following sacrifice two weeks later, the intraperitoneal adhesions were scored and tissues were examined histologically using HE staining.
Eight animals died, five in the untreated group (mortality rate, 12.5%), two in the HA group (mortality rate, 5.0%) and one in the Zn(2+)-SCMC group (mortality rate, 2.5%). Relative to the untreated group, the incidence of intraperitoneal adhesions was 77.5% in the HA and 48.7% in the Zn(2+)-SCMC group, with the incidence significantly lower in the Zn(2+)-SCMC group (P < 0.001). Both agents prevented intraperitoneal adhesions by promoting the repair of the abdominal serosa.
Administration of Zn(2+)-SCMC was more effective in preventing intraperitoneal adhesions than HA.
腹腔粘连是一种严重的术后并发症。我们通过大鼠模型比较了腹腔内给予锌修饰的羧甲基纤维素钠（Zn(2+)-SCMC）和透明质酸（HA）预防术后腹腔粘连的效果。
通过刮取盲肠黏膜在 120 只 Wistar 大鼠中诱导腹膜粘连。将大鼠随机分为无治疗组（n = 40）或治疗组，在关腹前腹腔内分别给予 3 ml 的 HA（n = 40）或 Zn(2+)-SCMC（n = 40）。两周后处死大鼠，根据粘连评分标准对腹腔内粘连进行评分，并通过 HE 染色对组织进行组织学检查。
8 只动物死亡，无治疗组 5 只（死亡率 12.5%），HA 组 2 只（死亡率 5.0%），Zn(2+)-SCMC 组 1 只（死亡率 2.5%）。与无治疗组相比，HA 组和 Zn(2+)-SCMC 组的腹腔粘连发生率分别为 77.5%和 48.7%，Zn(2+)-SCMC 组的发生率显著降低（P < 0.001）。两种药物均通过促进腹部浆膜修复来预防腹腔粘连。
与 HA 相比，Zn(2+)-SCMC 更有效地预防腹腔粘连。
