Smith G J, Ohl V S, Litwack G
Cancer Res. 1977 Jan;37(1):8-14.
The glutathione S-transferases are a major group of soluble liver proteins that are involved in the cellular detoxification of electrophilic compounds. Several of these transferases, in particular glutathione S-transferase B or ligandin, interact with chemical carcinogens in vivo. This review presents evidence that ligandin and the other glutathione S-transferases reduce the susceptibility of the liver to aminoazo dye-, polycyclic aromatic hydrocarbon-, and aromatic amine-induced carcinogenesis. Several possible mechanisms by which the transferases reduce hepatocarcinogenesis are proposed. These mechanisms include the direct binding and detoxification of carcinogens by the transferases and the inctivation of steroids and other agents that indirectly stimulate carcinogen activation.
谷胱甘肽S-转移酶是一组主要的可溶性肝脏蛋白质，参与亲电子化合物的细胞解毒过程。其中几种转移酶，特别是谷胱甘肽S-转移酶B或配体蛋白，在体内与化学致癌物相互作用。本综述提供的证据表明，配体蛋白和其他谷胱甘肽S-转移酶可降低肝脏对氨基偶氮染料、多环芳烃和芳香胺诱导的致癌作用的易感性。文中提出了转移酶降低肝癌发生的几种可能机制。这些机制包括转移酶对致癌物的直接结合和解毒，以及类固醇和其他间接刺激致癌物活化的物质的失活。
