Clifton G, Kaplowitz N
Cancer Res. 1977 Mar;37(3):788-91.
Glutathione S-transferase activities have been identified in the small intestine of the rat. Thrree activities obtained with p-nitrobenzyl chloride (aralkyl), 1,2-epoxy-3(p-nitrophenoxy)propane (epoxide), and ethacrynic acid (alkene) as substrates were present in significant amounts. Gel filtration indicated an elution volume for the intestinal transferase activities that was similar to those activities in the liver and kidney. The induction of the intestinal transferases by polycyclic aromatic hydrocarbons and phenobarbital is similar to those effects observed previously for the hepatic and renal enzymes. The highest concentration of transferase activities occurs in the proximal small intestine; these activities are reduced upon fasting. Parallel observations have been reported for aryl hydrocarbon hydroxylases. Because only low or negligible levels of epoxide hydrases have been reported in the small intestine, the glutathione S-transferases may be the primary epoxide-detoxifying system in that organ.
谷胱甘肽S-转移酶活性已在大鼠小肠中得到鉴定。以对硝基苄基氯（芳烷基）、1,2-环氧-3（对硝基苯氧基）丙烷（环氧化物）和依他尼酸（烯烃）作为底物获得的三种活性大量存在。凝胶过滤表明，肠道转移酶活性的洗脱体积与肝脏和肾脏中的那些活性相似。多环芳烃和苯巴比妥对肠道转移酶的诱导作用与先前观察到的对肝脏和肾脏酶的作用相似。转移酶活性的最高浓度出现在近端小肠；禁食时这些活性会降低。对于芳烃羟化酶也有类似的观察结果报道。由于在小肠中仅报道了低水平或可忽略不计的环氧化物水解酶，谷胱甘肽S-转移酶可能是该器官中主要的环氧化物解毒系统。
