Stebbins C L, Symons J D, McKirnan M D, Hwang F F
Department of Internal Medicine, University of California, Davis 95616.
Am J Physiol. 1994 Jan;266(1 Pt 2):R118-24. doi: 10.1152/ajpregu.1994.266.1.R118.
This study examined the effect of dynamic exercise on vasopressin release in the miniswine and factors that may elicit this response (n = 15). Thus lysine vasopressin (LVP), the catecholamines epinephrine and norepinephrine (EPI and NE), plasma renin activity (PRA), and plasma volume, Na+, and osmolality were measured before and during treadmill running at work intensities of 60, 80, and 100% of each swine's maximal heart rate reserve (HRR). LVP increased in a progressive manner similar to that of humans, ranging from 5.9 +/- 0.4 pg/ml before exercise to 30.1 +/- 4.5 pg/ml during maximal exercise. EPI, NE, and PRA [an index of angiotensin II (ANG II) activity] demonstrated a pattern of response comparable to LVP. Although these hormones can influence the release of LVP, only PRA displayed a strong correlation with LVP (r = 0.84). When ANG II synthesis was blocked (captopril, 1-3 mg/kg, intra-atrial injection) during exercise (80% HRR), plasma LVP was reduced from 9.9 +/- 0.6 to 7.5 +/- 0.6 pg/ml (P < 0.05). In addition, moderate-to-strong correlations were found between plasma concentrations of LVP and plasma osmolality (r = 0.79) and body temperature (r = 0.78). Plasma LVP also correlated with decreases in plasma volume (r = 0.84). These data suggest that the miniswine model is a good one for studying vasopressin effects during exercise and that ANG II appears to be a particularly strong stimulus for the release of this hormone.
本研究检测了动态运动对小型猪血管加压素释放的影响以及可能引发这种反应的因素（n = 15）。因此，在小型猪以其最大心率储备（HRR）的60%、80%和100%的工作强度在跑步机上跑步之前和期间，测量了赖氨酸血管加压素（LVP）、儿茶酚胺肾上腺素和去甲肾上腺素（EPI和NE）、血浆肾素活性（PRA）以及血浆容量、钠离子和渗透压。LVP的增加方式与人类相似，呈渐进性，从运动前的5.9±0.4 pg/ml增加到最大运动时的30.1±4.5 pg/ml。EPI、NE和PRA[血管紧张素II（ANG II）活性指标]表现出与LVP相当的反应模式。虽然这些激素可影响LVP的释放，但只有PRA与LVP表现出强相关性（r = 0.84）。在运动（80%HRR）期间，当ANG II合成被阻断（卡托普利，1 - 3 mg/kg，心房内注射）时，血浆LVP从9.9±0.6 pg/ml降至7.5±0.6 pg/ml（P < 0.05）。此外，发现血浆LVP浓度与血浆渗透压（r = 0.79）和体温（r = 0.78）之间存在中度至强相关性。血浆LVP还与血浆容量的减少相关（r = 0.84）。这些数据表明，小型猪模型是研究运动期间血管加压素作用的良好模型，并且ANG II似乎是该激素释放的特别强烈的刺激因素。
