Sapena R, Morin D, Zini R, Tillement J P
Département de pharmacologie (1), Faculté de Médecine de Paris XII, Creteil, France.
Biochem Pharmacol. 1994 Jan 20;47(2):175-8. doi: 10.1016/0006-2952(94)90003-5.
The interaction of isoproterenol with beta-adrenoceptors has been investigated in astroglial and neuronal cells isolated from adult rat cerebral cortices. Using the non-selective beta-adrenergic antagonist (3H)CGP-12177 as a ligand, binding experiments revealed that both types of cells exhibit beta-adrenoceptors. However the analysis of the isoproterenol displacement curve indicated that only neuronal cells contained the high affinity conformational state of the beta-adrenoceptor.
已在从成年大鼠大脑皮层分离出的星形胶质细胞和神经元细胞中研究了异丙肾上腺素与β-肾上腺素能受体的相互作用。使用非选择性β-肾上腺素能拮抗剂（3H）CGP-12177作为配体，结合实验表明两种类型的细胞均表现出β-肾上腺素能受体。然而，对异丙肾上腺素置换曲线的分析表明，只有神经元细胞含有β-肾上腺素能受体的高亲和力构象状态。
