Albero M I, Sánchez-Petreño C, García M S, Ródenas V
Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, Spain.
J Pharm Biomed Anal. 1993 Oct;11(10):887-91. doi: 10.1016/0731-7085(93)80045-3.
A flow injection spectrophotometric method for the determination of captopril involving measurement of the absorbance of the captopril complex with palladium(II) in a 0.12 M HCl medium at 400 nm is presented. The calibration graph was linear over the range 2 x 10(-5)-6 x 10(-4) M. The sampling frequency was 90 h-1 with sample injections of 70 microliters. The proposed method was applied to the determination of captopril in pharmaceutical samples.
提出了一种流动注射分光光度法测定卡托普利，该方法是通过测量在0.12 M盐酸介质中卡托普利与钯（II）配合物在400 nm处的吸光度来进行的。校准曲线在2×10⁻⁵ - 6×10⁻⁴ M范围内呈线性。进样量为70微升时，采样频率为90次/小时。该方法已应用于药物样品中卡托普利的测定。
