Palomeque Miriam E, Band Beatriz S Fernández
Department of Chemistry and Eng Chemistry, FIA Laboratory, Universidad Nacional del Sur, Av Alem 1253, 8000 Bahía Blanca, Argentine.
J Pharm Biomed Anal. 2002 Oct 15;30(3):547-52. doi: 10.1016/s0731-7085(02)00315-1.
An automated method to determine captopril (1-[(2S)-3-mercapto-2-methylpropionyl]-L-proline) is proposed. A flow injection manifold based on the indirect biamperometric detection of the captopril by using Fe(III)/Fe(II) as an indicating redox system and a Z-shaped flow-cell configuration, was developed. The calibration curve is linear over the range 0.03-3.6 microg ml(-1) of captopril. The relative standard deviation for the determination of 0.76 microg ml(-1) of captopril is 0.97% (n = 12) and the sample throughput is 69 h(-1). This method was applied to the determination of captopril to commercially available pharmaceutical preparations.
