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The leukocyte common antigen, CD45 and other protein tyrosine phosphatases in hematopoietic cells.

作者信息

Woodford-Thomas T, Thomas M L

机构信息

Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110.

出版信息

Semin Cell Biol. 1993 Dec;4(6):409-18. doi: 10.1006/scel.1993.1049.

DOI:10.1006/scel.1993.1049
PMID:8305680
Abstract

Numerous protein tyrosine phosphatases have been characterized that are expressed by hematopoietic-derived cells. CD45, a transmembrane protein tyrosine phosphatase expressed by all nucleated cells of hematopoietic origin, has been a prototype for studying the function of these enzymes. In T lymphocytes, CD45 serves to dephosphorylate and activate members of the Src-tyrosine kinase family. Without CD45 function, T cells cannot respond to antigen. Therefore, CD45 functions positively to regulate lymphocyte activation. The characteristics of other protein tyrosine phosphatases found in hematopoietic-derived cells suggests that they are also essential in regulating cell differentiation and activation.

摘要

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