Falchuk K R, Jacoby I, Colucci W S, Rybak M E
Gastroenterology. 1977 Feb;72(2):319-21.
Two patients with cirrhosis and ascites complicated by extensive unilateral pleural transudates refractory to therapy with dietary sodium restriction, diuretics, and repeated thoracentesis were successfully managed by tetracycline-induced pleural symphysis. The intrapleural instillation of this antibiotic prevented the recurrence of the effusion and substantially relieved the patients' symptoms with minimal undesirable side effects.
两名肝硬化腹水患者并发广泛性单侧胸腔漏出液，对限钠饮食、利尿剂及反复胸腔穿刺治疗无效，采用四环素诱导胸膜粘连成功治愈。胸腔内注入这种抗生素可防止胸腔积液复发，并以最小的不良反应显著缓解了患者症状。
