Twomey B M, Amin V, Isenberg D A, Latchman D S
Department of Molecular Pathology, University College London Medical School, UK.
Lupus. 1993 Oct;2(5):297-301. doi: 10.1177/096120339300200504.
The level of the heat inducible hsp70 protein (hsp72) has been shown to be elevated in the peripheral blood mononuclear cells of a subset of SLE patients. We show that this increased level of hsp70 is not dependent on enhanced transcription of the hsp70 gene or elevated levels of the hsp70 mRNA, neither of which are observed in SLE patients with enhanced protein levels. This indicates that posttranscriptional processes involving either improved translatability of the hsp70 mRNA or increased protein stability are responsible for the observed increase in protein levels in these patients.
热诱导型hsp70蛋白（hsp72）水平已在部分系统性红斑狼疮（SLE）患者的外周血单个核细胞中被证实有所升高。我们发现，hsp70这种升高的水平并不依赖于hsp70基因转录增强或hsp70 mRNA水平升高，在蛋白水平升高的SLE患者中均未观察到这两种情况。这表明，涉及hsp70 mRNA翻译能力提高或蛋白质稳定性增加的转录后过程，是这些患者中观察到的蛋白质水平升高的原因。
