清醒大鼠对静脉内和动脉内给予内皮素-1及大内皮素-1的局部血流动力学反应。

Regional haemodynamic responses to intravenous and intraarterial endothelin-1 and big endothelin-1 in conscious rats.

作者信息

Gardiner S M, Kemp P A, Bennett T

机构信息

Department of Physiology and Pharmacology, University of Nottingham Medical School, Queen's Medical Centre.

出版信息

Br J Pharmacol. 1993 Dec;110(4):1532-6. doi: 10.1111/j.1476-5381.1993.tb13997.x.

DOI:10.1111/j.1476-5381.1993.tb13997.x

PMID:8306098

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2175838/

Abstract

In the same chronically-instrumented conscious Long Evans rats, we assessed regional haemodynamic responses to i.v. and i.a. injections of endothelin-1 (ET-1) and big endothelin-1 at doses of 0.05 (n = 4) and 0.5 nmol kg-1 (n = 7). 2. For ET-1, the cardiovascular effects (initial hypotension and tachycardia with transient hindquarters vasodilation, followed by hypertension, bradycardia and renal, mesenteric and hindquarters vasoconstrictions) of i.v. and i.a. injections were not different. 3. Similarly, for big ET-1, the cardiovascular effects (hypertension, bradycardia and renal, mesenteric, and hindquarters vasoconstrictions) of i.v. and i.a. injections were not different. 4. At a dose of 0.5 nmol kg-1, i.v. or i.a., the pressor effects of ET-1 and big ET-1 were not different(area under curve [AUCO-30m.), ET-1 i.v. = 786 +/- 115 mmHg min; ET-1 i.a. = 880 +/- 165 mmHg min;big ET-1 i.v. = 878 +/- 93 mmHg min; big ET-1 i.a. = 833 +/- 103 mmHg min); but ET-1 caused greater renal, and lesser hindquarters, vasoconstrictions than big ET-1 (renal ET-1 i.v., AOC = 1550 +/- 211%min; ET-1 i.a., AOC = 1746 +/- 139% min; big ET-1 i.v., AOC = 1097 +/- 128% min; big ET-1 i.a.,AOC = 1041 +/- 119% min; hindquarters, ET-1 i.v., AOC = 758 +/- 176% min; ET-1 i.a. AOC =787 +/- 184% min; big ET-1 i.v., AOC = 1270 +/- 88% min; big ET-1 i.a., AOC = 1173 +/- 77% min), while the mesenteric vasoconstrictor effects of both peptides were not significantly different (ET-1 i.v.AOC = 1419 +/- 132% min; ET-l i.a., AOC = 1526 +/- 172% min; big ET-1 i.v., AOC = 1099 +/- 166%min; big ET-1 i.a., AOC = 1155 +/- 120% min).5. Under the conditions of our experiments, pulmonary clearance of ET-1, or pulmonary activation of big ET-1, was not apparent from the haemodynamic responses to i.v. and i.a. administration of the peptides. The results are consistent with previous findings indicating that local, rather than systemic,conversion of exogenous big ET-1 to ET-1 is responsible for its regional haemodynamic actions.

摘要

在同一批长期植入仪器的清醒Long Evans大鼠中，我们评估了静脉注射和动脉注射剂量为0.05（n = 4）和0.5 nmol kg-1（n = 7）的内皮素-1（ET-1）和大内皮素-1后局部血流动力学反应。2. 对于ET-1，静脉注射和动脉注射的心血管效应（初始低血压和心动过速伴短暂后肢血管舒张，随后是高血压、心动过缓和肾、肠系膜及后肢血管收缩）并无差异。3. 同样，对于大内皮素-1，静脉注射和动脉注射的心血管效应（高血压、心动过缓和肾、肠系膜及后肢血管收缩）也无差异。4. 在0.5 nmol kg-1的剂量下，静脉注射或动脉注射时，ET-1和大内皮素-1的升压效应并无差异（曲线下面积[AUCO-30m.]，ET-1静脉注射= 786±115 mmHg·min；ET-1动脉注射= 880±165 mmHg·min；大内皮素-1静脉注射= 878±93 mmHg·min；大内皮素-1动脉注射= 833±103 mmHg·min）；但ET-1引起的肾血管收缩大于大内皮素-1，而后肢血管收缩小于大内皮素-1（肾，ET-1静脉注射，AOC = 1550±211%·min；ET-1动脉注射，AOC = 1746±139%·min；大内皮素-1静脉注射，AOC = 1097±128%·min；大内皮素-1动脉注射，AOC = 1041±119%·min；后肢，ET-1静脉注射，AOC = 758±176%·min；ET-1动脉注射，AOC = 787±184%·min；大内皮素-1静脉注射，AOC = 1270±88%·min；大内皮素-1动脉注射，AOC = 1173±77%·min），而两种肽的肠系膜血管收缩效应无显著差异（ET-1静脉注射，AOC = 1419±132%·min；ET-1动脉注射，AOC = 1526±172%·min；大内皮素-1静脉注射，AOC = 1099±166%·min；大内皮素-1动脉注射，AOC = 1155±120%·min）。5. 在我们的实验条件下，从对肽进行静脉注射和动脉注射后的血流动力学反应来看，ET-1的肺清除或大内皮素-1的肺激活并不明显。这些结果与先前的发现一致，表明外源性大内皮素-1局部而非全身转化为ET-1是其局部血流动力学作用的原因。

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本文引用的文献

Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.

Proc Natl Acad Sci U S A. 1988 Dec;85(24):9797-800. doi: 10.1073/pnas.85.24.9797.

NG-monomethyl-L-arginine does not inhibit the hindquarters vasodilator action of endothelin-1 in conscious rats.

Eur J Pharmacol. 1989 Nov 21;171(2-3):237-40. doi: 10.1016/0014-2999(89)90113-1.

Tissue specific distribution, clearance and vascular effects of endothelin in the pig.

Biochem Biophys Res Commun. 1989 Jun 15;161(2):647-53. doi: 10.1016/0006-291x(89)92648-x.

Endothelin produces pulmonary vasoconstriction and systemic vasodilation.

J Appl Physiol (1985). 1989 Feb;66(2):1008-12. doi: 10.1152/jappl.1989.66.2.1008.

Elimination of intravenously injected endothelin-1 from the circulation of the rat.

J Cardiovasc Pharmacol. 1989;13 Suppl 5:S98-101; discussion S102. doi: 10.1097/00005344-198900135-00024.

The fate of radioiodinated endothelin-1 and endothelin-3 in the rat.

J Cardiovasc Pharmacol. 1989;13 Suppl 5:S46-9; discussion S74. doi: 10.1097/00005344-198900135-00012.

Vasodilation induced by endothelin: role of EDRF and prostanoids in rat hindquarters.

Am J Physiol. 1990 Dec;259(6 Pt 2):H1835-41. doi: 10.1152/ajpheart.1990.259.6.H1835.

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Phosphoramidon, a metalloproteinase inhibitor, suppresses the hypertensive effect of big endothelin-1.

Eur J Pharmacol. 1990 Aug 21;185(1):103-6. doi: 10.1016/0014-2999(90)90216-s.

Effects of indomethacin on the regional haemodynamic responses to low doses of endothelins and sarafotoxin.

Br J Pharmacol. 1990 May;100(1):158-62. doi: 10.1111/j.1476-5381.1990.tb12069.x.

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清醒大鼠对静脉内和动脉内给予内皮素-1及大内皮素-1的局部血流动力学反应。

Regional haemodynamic responses to intravenous and intraarterial endothelin-1 and big endothelin-1 in conscious rats.

作者信息

Gardiner S M, Kemp P A, Bennett T

机构信息

Department of Physiology and Pharmacology, University of Nottingham Medical School, Queen's Medical Centre.

出版信息

Br J Pharmacol. 1993 Dec;110(4):1532-6. doi: 10.1111/j.1476-5381.1993.tb13997.x.

DOI:10.1111/j.1476-5381.1993.tb13997.x

PMID:8306098

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2175838/

Abstract

In the same chronically-instrumented conscious Long Evans rats, we assessed regional haemodynamic responses to i.v. and i.a. injections of endothelin-1 (ET-1) and big endothelin-1 at doses of 0.05 (n = 4) and 0.5 nmol kg-1 (n = 7). 2. For ET-1, the cardiovascular effects (initial hypotension and tachycardia with transient hindquarters vasodilation, followed by hypertension, bradycardia and renal, mesenteric and hindquarters vasoconstrictions) of i.v. and i.a. injections were not different. 3. Similarly, for big ET-1, the cardiovascular effects (hypertension, bradycardia and renal, mesenteric, and hindquarters vasoconstrictions) of i.v. and i.a. injections were not different. 4. At a dose of 0.5 nmol kg-1, i.v. or i.a., the pressor effects of ET-1 and big ET-1 were not different(area under curve [AUCO-30m.), ET-1 i.v. = 786 +/- 115 mmHg min; ET-1 i.a. = 880 +/- 165 mmHg min;big ET-1 i.v. = 878 +/- 93 mmHg min; big ET-1 i.a. = 833 +/- 103 mmHg min); but ET-1 caused greater renal, and lesser hindquarters, vasoconstrictions than big ET-1 (renal ET-1 i.v., AOC = 1550 +/- 211%min; ET-1 i.a., AOC = 1746 +/- 139% min; big ET-1 i.v., AOC = 1097 +/- 128% min; big ET-1 i.a.,AOC = 1041 +/- 119% min; hindquarters, ET-1 i.v., AOC = 758 +/- 176% min; ET-1 i.a. AOC =787 +/- 184% min; big ET-1 i.v., AOC = 1270 +/- 88% min; big ET-1 i.a., AOC = 1173 +/- 77% min), while the mesenteric vasoconstrictor effects of both peptides were not significantly different (ET-1 i.v.AOC = 1419 +/- 132% min; ET-l i.a., AOC = 1526 +/- 172% min; big ET-1 i.v., AOC = 1099 +/- 166%min; big ET-1 i.a., AOC = 1155 +/- 120% min).5. Under the conditions of our experiments, pulmonary clearance of ET-1, or pulmonary activation of big ET-1, was not apparent from the haemodynamic responses to i.v. and i.a. administration of the peptides. The results are consistent with previous findings indicating that local, rather than systemic,conversion of exogenous big ET-1 to ET-1 is responsible for its regional haemodynamic actions.

摘要

在同一批长期植入仪器的清醒Long Evans大鼠中，我们评估了静脉注射和动脉注射剂量为0.05（n = 4）和0.5 nmol kg-1（n = 7）的内皮素-1（ET-1）和大内皮素-1后局部血流动力学反应。2. 对于ET-1，静脉注射和动脉注射的心血管效应（初始低血压和心动过速伴短暂后肢血管舒张，随后是高血压、心动过缓和肾、肠系膜及后肢血管收缩）并无差异。3. 同样，对于大内皮素-1，静脉注射和动脉注射的心血管效应（高血压、心动过缓和肾、肠系膜及后肢血管收缩）也无差异。4. 在0.5 nmol kg-1的剂量下，静脉注射或动脉注射时，ET-1和大内皮素-1的升压效应并无差异（曲线下面积[AUCO-30m.]，ET-1静脉注射= 786±115 mmHg·min；ET-1动脉注射= 880±165 mmHg·min；大内皮素-1静脉注射= 878±93 mmHg·min；大内皮素-1动脉注射= 833±103 mmHg·min）；但ET-1引起的肾血管收缩大于大内皮素-1，而后肢血管收缩小于大内皮素-1（肾，ET-1静脉注射，AOC = 1550±211%·min；ET-1动脉注射，AOC = 1746±139%·min；大内皮素-1静脉注射，AOC = 1097±128%·min；大内皮素-1动脉注射，AOC = 1041±119%·min；后肢，ET-1静脉注射，AOC = 758±176%·min；ET-1动脉注射，AOC = 787±184%·min；大内皮素-1静脉注射，AOC = 1270±88%·min；大内皮素-1动脉注射，AOC = 1173±77%·min），而两种肽的肠系膜血管收缩效应无显著差异（ET-1静脉注射，AOC = 1419±132%·min；ET-1动脉注射，AOC = 1526±172%·min；大内皮素-1静脉注射，AOC = 1099±166%·min；大内皮素-1动脉注射，AOC = 1155±120%·min）。5. 在我们的实验条件下，从对肽进行静脉注射和动脉注射后的血流动力学反应来看，ET-1的肺清除或大内皮素-1的肺激活并不明显。这些结果与先前的发现一致，表明外源性大内皮素-1局部而非全身转化为ET-1是其局部血流动力学作用的原因。

清醒大鼠对静脉内和动脉内给予内皮素-1及大内皮素-1的局部血流动力学反应。

Regional haemodynamic responses to intravenous and intraarterial endothelin-1 and big endothelin-1 in conscious rats.

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清醒大鼠对静脉内和动脉内给予内皮素-1及大内皮素-1的局部血流动力学反应。

Regional haemodynamic responses to intravenous and intraarterial endothelin-1 and big endothelin-1 in conscious rats.

作者信息

机构信息

出版信息