一种在估计自发突变率时考虑接种效率的算法。

An algorithm accounting for plating efficiency in estimating spontaneous mutation rates.

作者信息

Jones M E

机构信息

School of Medicine, Flinders University, Adelaide, Australia.

出版信息

Comput Biol Med. 1993 Nov;23(6):455-61. doi: 10.1016/0010-4825(93)90093-g.

DOI:10.1016/0010-4825(93)90093-g

PMID:8306624

Abstract

An algorithm is described for calculating the probability distribution of the number of mutant colonies arising in a Luria-Delbrück fluctuation experiment subject to a plating efficiency of less than 100%. A table is constructed to facilitate the estimation of spontaneous mutation rates taking into account the plating efficiency.

摘要

本文描述了一种算法，用于计算在平板接种效率低于100%的卢里亚-德尔布吕克波动实验中出现的突变菌落数的概率分布。构建了一个表格，以便在考虑平板接种效率的情况下估计自发突变率。