Sherman D M, Trach V M
Gematol Transfuziol. 1993 Sep-Oct;38(8):27-30.
Acute experiments on 63 adult rabbits have shown that acute divided blood loss for 5 min (27 +/- 1% of the whole blood volume) results in the development of reversible hemorrhagic shock with survival of all the animals. In the same volume of continuous blood exfusion (27 +/- 5% of blood volume) or an increase in blood loss to 43 +/- 2% of blood volume hemorrhagic shock proved irreversible. Early reinfusion of heparinized blood saved all the animals, whereas late reinfusions only prolonged the survival. Intravenous administration of dalargin (0.1 mg/kg) in late shock was not effective and all the animals died. Dalargin introduction after blood reinfusion in late shock saved the animals lives. The conclusion is made on benefits of intravenous dalargin for raising the efficacy of reinfusions (hemotransfusion) at late stages of severe hemorrhagic shock.
对63只成年兔进行的急性实验表明，5分钟内急性分次失血（占全血量的27±1%）会导致可逆性失血性休克，所有动物均存活。同等血量的持续输血（占血量的27±5%）或失血量增加至占血量的43±2%时，失血性休克被证明是不可逆的。早期输注肝素化血液可挽救所有动物，而晚期输注仅能延长存活时间。晚期休克时静脉注射达拉根（0.1毫克/千克）无效，所有动物均死亡。晚期休克输血后注射达拉根可挽救动物生命。得出的结论是，静脉注射达拉根有利于提高严重失血性休克晚期再输注（输血）的疗效。
