小鼠CTP：磷酸胆碱胞苷转移酶（Ctpct）的基因位于小鼠16号染色体上。
The gene for murine CTP:phosphocholine cytidylyltransferase (Ctpct) is located on mouse chromosome 16.
作者信息
Rutherford M S, Rock C O, Jenkins N A, Gilbert D J, Tessner T G, Copeland N G, Jackowski S
机构信息
Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, Tennessee 38101.
出版信息
Genomics. 1993 Dec;18(3):698-701. doi: 10.1016/s0888-7543(05)80377-5.
CTP
phosphocholine cytidylyltransferase is the rate-controlling enzyme in phosphatidylcholine biosynthesis and is essential for the survival of eukaryotic cells. The murine cDNA for the cytidylyltransferase was cloned and sequenced. A genomic clone was isolated and the chromosomal location of the Ctpct locus determined by Southern blot hybridization of DNAs from a panel of interspecific backcross progeny derived from matings of [(C57BL/6J x Mus spretus)F1 x C57BL/6J] mice. These data place the Ctpct gene on mouse chromosome 16 between the Smst and Stf-1 genes.
CTP
磷酸胆碱胞苷转移酶是磷脂酰胆碱生物合成中的限速酶，对真核细胞的存活至关重要。克隆并测序了胞苷转移酶的小鼠cDNA。分离出一个基因组克隆，并通过对一组源自[(C57BL/6J×小家鼠)F1×C57BL/6J]小鼠杂交后代的种间回交子代DNA进行Southern印迹杂交，确定了Ctpct基因座的染色体定位。这些数据将Ctpct基因定位于小鼠16号染色体上Smst和Stf-1基因之间。
Zotero 插件