着床后数天小鼠子宫和胚胎中母体免疫球蛋白的分布
Distribution of maternal immunoglobulins in the mouse uterus and embryo in the days after implantation.
作者信息
Bernard O, Ripoche M A, Bennett D
出版信息
J Exp Med. 1977 Jan 1;145(1):58-75. doi: 10.1084/jem.145.1.58.
Abstract
The distribution of maternal immunoglobulins in the mouse uterus and embryo in the days after implantation has been studied on sections incubated with sheep Fab anti-mouse immunoglobulins labeled with peroxidase. At the time of implantation the blastocyst is already surrounded by immunoglobulins that are also present in the blastocoel and early endoderm; uterine glands contain large amounts of immunoglobulins. Later, immunoglobulins are concentrated in the vacuolated endoderm, then the visceral yolk sac and the embryonic gut. They are also present in the various cavities of the embryo. Trophoblast cells progressively contain increasing amounts of immunoglobulins. In the decidua, immunoglobulins coat the cells and also occasionally appear as cytoplasmic granules. The early presence of maternal immunoglobulins may represent the transfer of serum proteins as a means of nutrition for the embryo. It is also very likely to have an immunological significance in the protection of the embryo.
摘要
利用与过氧化物酶标记的羊抗小鼠免疫球蛋白孵育的切片，研究了植入后数天内母体免疫球蛋白在小鼠子宫和胚胎中的分布情况。植入时，胚泡已被免疫球蛋白包围，这些免疫球蛋白也存在于胚泡腔和早期内胚层中；子宫腺含有大量免疫球蛋白。后来，免疫球蛋白集中在空泡化的内胚层，然后是脏卵黄囊和胚胎肠道。它们也存在于胚胎的各个腔隙中。滋养层细胞逐渐含有越来越多的免疫球蛋白。在蜕膜中，免疫球蛋白覆盖细胞，偶尔也表现为细胞质颗粒。母体免疫球蛋白的早期存在可能代表血清蛋白的转移，作为胚胎营养的一种方式。它很可能在保护胚胎方面具有免疫学意义。
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