Dantas R O, Meneghelli U G, Oliveira R B, Villanova M G
Department of Internal Medicine, Faculty of Medicine, Ribeirão Preto University of São Paulo, Brazil.
J Clin Gastroenterol. 1993 Dec;17(4):281-5. doi: 10.1097/00004836-199312000-00003.
Using the manometric method, we studied the progression of esophageal involvement in 17 women with a diagnosis of systemic sclerosis (SSc) and compared the results with those obtained for 14 healthy women. The manometric examination of SSc patients was performed twice, with an interval of 9 to 111 months (median, 40 months). All patients had peristaltic contractions in the proximal esophagus. Eight had peristaltic contractions, and 9 had no contraction in the middle and distal esophagus. The lower esophageal sphincter pressure and the amplitude of contractions in the esophageal body were lower in SSc patients than in controls. The duration of contractions was the same in SSc patients and controls. The velocity of peristaltic contractions did not differ between patients and controls in the distal esophagus, but was higher in SSc patients in the proximal esophagus. In 16 patients, no difference in lower esophageal sphincter (LES) pressure, esophageal contraction amplitude, duration, and velocity was observed between the first and second evaluation. In one patient, the distal esophageal contractions changed from peristaltic to completely absent, and the lower esophageal sphincter pressure changed from 20.2 mm Hg to 5.1 mm Hg. The results suggest that the esophageal involvement of SSc patients was not progressive in all cases.
我们采用测压法研究了17例诊断为系统性硬化症（SSc）的女性患者食管受累情况的进展，并将结果与14例健康女性的结果进行了比较。对SSc患者的测压检查进行了两次，间隔时间为9至111个月（中位数为40个月）。所有患者近端食管均有蠕动收缩。8例患者中、远端食管有蠕动收缩，9例无收缩。SSc患者的食管下括约肌压力和食管体部收缩幅度低于对照组。SSc患者和对照组的收缩持续时间相同。患者和对照组远端食管蠕动收缩速度无差异，但SSc患者近端食管蠕动收缩速度较高。16例患者在第一次和第二次评估之间，食管下括约肌（LES）压力、食管收缩幅度、持续时间和速度均无差异。1例患者远端食管收缩从蠕动性变为完全消失，食管下括约肌压力从20.2 mmHg变为5.1 mmHg。结果表明，并非所有SSc患者的食管受累情况都会进展。
