Satake K, Hongo M, Ujiie H, Okuno Y, Toyota T, Lin Y F
Third Department of Internal Medicine, Tohoku University School of Medicine.
Nihon Shokakibyo Gakkai Zasshi. 1990 Aug;87(8):1629-35.
Progressive systemic sclerosis (PSS) commonly involves the esophagus. Dysphagia and heartburn are the most common esophageal symptoms. In this study we evaluated the relationship between esophageal symptoms and esophago-gastric motility. On esophageal manometry, loss of peristalsis, peristaltic contraction amplitude of distal esophagus less than 30 mmHg and decreased LES pressure were critical for esophageal symptoms. The degree of symptoms correlated to esophageal dysmotility. The gastric emptying in PSS patients was delayed, but there was no significant difference in gastric emptying between the patients with and without reflux esophagitis. Esophageal dysmotility is considered to be much responsible for the reflux esophagitis in PSS patients than gastric emptying.
进行性系统性硬化症（PSS）常累及食管。吞咽困难和烧心是最常见的食管症状。在本研究中，我们评估了食管症状与食管-胃动力之间的关系。食管测压显示，蠕动消失、食管远端蠕动收缩幅度小于30 mmHg以及LES压力降低是出现食管症状的关键因素。症状程度与食管动力障碍相关。PSS患者的胃排空延迟，但有反流性食管炎和无反流性食管炎的患者之间胃排空无显著差异。与胃排空相比，食管动力障碍被认为在PSS患者的反流性食管炎中起更大作用。
