Walski M, Celary-Walska R, Borowicz J
Laboratory of the Ultrastructure of the Nervous System, Medical Research Centre, Polish Academy of Sciences, Warsaw.
J Hirnforsch. 1993;34(4):503-15.
The aim of the study was to investigate the area surrounding precapillary vessels in the temporal cortex of rat-brains. The material consisted of animals that survived a 10-minute cardiac arrest and then lived on for 10 to 12 months. In the specimens that survived 10 month we observed dilatation of the pericapillary space pervaded with unidentified cells surrounded by multiple collagen fibrils. In the close vicinity of these vessels we often discerned cells participating in the process of phagocytosis. Smooth muscle cells held numerous pinocytic vesicles which contained microfibrillar material. Collagen fibrils were also discerned beneath their basement membrane. In the animals that survived 12 months in many cases the spaces between blood vessel mural myocytes and brain cells were filled with numerous collagen fibrils. In some cases these fibrils formed bridge-like structures between vessel walls and surrounding nerve cells. These compartments were often accompanied by brain phagocytes, the cytoplasm of which contained single fibres or bundles of collagen located in the close proximity of the phagolysosomes. We discussed the role of myocytes, myofibroblasts and phagocytes in the production of reparative collagen following the destruction of precapillary vessels and brain continuity.
该研究的目的是调查大鼠脑颞叶皮质中毛细血管前血管周围的区域。材料包括经历了10分钟心脏骤停后存活并继续存活10至12个月的动物。在存活10个月的标本中，我们观察到毛细血管周围间隙扩张，充满了被多条胶原纤维包围的不明细胞。在这些血管的紧邻区域，我们经常能辨别出参与吞噬过程的细胞。平滑肌细胞含有大量含有微纤维物质的吞饮小泡。在其基底膜下方也能辨别出胶原纤维。在存活12个月的动物中，在许多情况下，血管壁肌细胞和脑细胞之间的间隙充满了大量胶原纤维。在某些情况下，这些纤维在血管壁和周围神经细胞之间形成桥状结构。这些区域常伴有脑吞噬细胞，其细胞质中含有位于吞噬溶酶体附近的单根纤维或胶原束。我们讨论了肌细胞、肌成纤维细胞和吞噬细胞在毛细血管前血管破坏和脑连续性破坏后修复性胶原产生中的作用。
