Welch M J, Coleman R E, Straatmann M G, Asberry B E, Primeau J L, Fair W R, Ter-Pogossian M M
J Nucl Med. 1977 Jan;18(1):74-8.
The polyamines putrescine, spermine, and spermidine were methylated by the addition of carbon-11-labeled formaledehyde followed by sodium borohydride. High labeling yields wrbon-11-labeled formaldehyde followed by sodium borohydride. High labeling yields were obtained and the final products were purified by simply boiling the solution. This decomposed the excess sodium borohydride and removed the volatile impurities. The final radiochemical purity of all the methylated compounds was above 85%. All three methyltated compounds accumulated in the prostates of male rats and the distribution of N-methyl-1,4-diaminobutane (the putrescine analog) was very similar to that previously obtained with tritiated putrescine. The uptake of the putrescine analog in both the prostate and in mouse tumor was slightly higher than that obtained with the other two analogs studied. Utilizing a positron transaxial tomographic scanner and the putrescine analog, we have been able to image the prostate gland of a dog.
通过添加碳-11标记的甲醛，随后加入硼氢化钠，对多胺腐胺、精胺和亚精胺进行甲基化。标记产率较高，标记后使用硼氢化钠。获得了较高的标记产率，最终产物通过简单煮沸溶液进行纯化。这分解了过量的硼氢化钠并去除了挥发性杂质。所有甲基化化合物的最终放射化学纯度均高于85%。所有三种甲基化化合物都在雄性大鼠的前列腺中积累，N-甲基-1,4-二氨基丁烷（腐胺类似物）的分布与先前用氚标记的腐胺所获得的分布非常相似。腐胺类似物在前列腺和小鼠肿瘤中的摄取略高于所研究的其他两种类似物。利用正电子断层扫描仪和腐胺类似物，我们已经能够对狗的前列腺进行成像。
