Goldman S S, Volkow N D, Brodie J, Flamm E S
J Neurooncol. 1986;4(1):23-9. doi: 10.1007/BF02157998.
The metabolism of the polyamines, putrescine, spermidine and spermine, was studied in human brain and brain tumors. Samples of brain and tumors were incubated with 3H-putrescine and the amounts of labeled polyamines were measured. The amount of putrescine conversion was found to be greater in tumors that in normal brain samples. Furthermore, the metabolism of putrescine in brain tumors was related to tumor type and appeared to correlate with the degree of malignancy. The significance of these findings with regard to positron emission tomographic scanning and therapy of patients with malignant gliomas is discussed.
对人脑中多胺（腐胺、亚精胺和精胺）的代谢进行了研究，并与脑肿瘤中的代谢情况作对比。将脑和肿瘤样本与³H-腐胺一起孵育，然后测量标记多胺的量。结果发现，肿瘤中腐胺的转化量比正常脑样本中的更大。此外，脑肿瘤中腐胺的代谢与肿瘤类型有关，并且似乎与恶性程度相关。本文还讨论了这些发现对于正电子发射断层扫描以及恶性胶质瘤患者治疗的意义。
