Price E A, D'Alessandro A, Kearney T, Olson K R, Blanc P D
San Francisco Bay Area Poison Control Center, California.
J Toxicol Clin Toxicol. 1994;32(1):79-84. doi: 10.3109/15563659409000434.
Methyl ethyl ketone is a common solvent but data on overdose in humans are scarce. We report a case of co-ingestion of methyl ethyl ketone together with methanol associated with a hyperosmolar coma without anion gap metabolic acidosis. Blood levels of methyl ethyl ketone and its metabolite, 2-butanol, indicated that this solvent did contribute approximately 20 mosm/L to an observed osmolar gap of 99 mosm/L. At the levels detected, methyl ethyl ketone may have inhibited methanol metabolism, contributing to the low serum formate (1.3 mmol/L) and normal anion gap despite a blood methanol of 67 mmol/L.
甲乙酮是一种常见的溶剂，但关于人类过量摄入的资料很少。我们报告了一例甲乙酮与甲醇共同摄入导致高渗性昏迷但无阴离子间隙代谢性酸中毒的病例。甲乙酮及其代谢物2-丁醇的血药浓度表明，这种溶剂对观察到的99 mosm/L的渗透压间隙贡献了约20 mosm/L。在检测到的浓度水平下，甲乙酮可能抑制了甲醇代谢，尽管血液甲醇浓度为67 mmol/L，但导致血清甲酸水平较低（1.3 mmol/L）且阴离子间隙正常。
