Sakata M, Kikuchi J, Haga M, Ishiyama N, Maeda T, Ise T, Hikita N
Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University, Ishikari, Japan.
J Toxicol Clin Toxicol. 1989;27(1-2):67-77. doi: 10.3109/15563658909038570.
A case of coma due to the drinking of a liquid cement for polyvinyl chloride resin, containing acetone, methyl ethyl ketone, cyclohexanone and polyvinyl chloride is described. The patient also simultaneously ingested the alcoholic beverage, sake. After gastric lavage, plasma exchanges and direct hemoperfusions, the patient recovered. The concentrations of these chemicals in plasma and urine were analyzed at various time intervals to estimate the clearance. The elimination half lives for acetone and methyl ethyl ketone were 18 hours and 10 hours, respectively. Although cyclohexanone made up the largest component in the solvents, the blood level was extremely low and a large amount of cyclohexanol, a metabolite of cyclohexanone was detected in the blood and urine. The glucuronide metabolite of cyclohexanol was also estimated after the hydrolysis with beta-glucuronidase. Since the conversion of cyclohexanone to cyclohexanol is known to be catalyzed by alcohol dehydrogenase, possible interactions between sake ingestion and cyclohexanone metabolism is proposed.
本文描述了一例因饮用含有丙酮、甲乙酮、环己酮和聚氯乙烯的聚氯乙烯树脂液体胶而导致昏迷的病例。患者同时还摄入了酒精饮料清酒。经过洗胃、血浆置换和直接血液灌流后，患者康复。在不同时间间隔分析血浆和尿液中这些化学物质的浓度以估计清除率。丙酮和甲乙酮的消除半衰期分别为18小时和10小时。尽管环己酮在溶剂中占比最大，但血液水平极低，且在血液和尿液中检测到大量环己酮的代谢产物环己醇。在用β-葡萄糖醛酸酶水解后，还对环己醇的葡萄糖醛酸代谢产物进行了评估。由于已知环己酮向环己醇的转化由乙醇脱氢酶催化，因此提出了清酒摄入与环己酮代谢之间可能的相互作用。
